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<span style="font-size: 10pt; font-family: Arial;" data-sheets-root="1">Sublocade, a long-acting form of buprenorphine, can remain in your system for up to 2 to 5 months after the last dose. The exact duration depends on metabolism, dosage, and individual health factors. It is designed to provide extended relief from opioid cravings and dependence.</span>How Long Does Sublocade Stay In Your System?